2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK) Insulin Receptor VEGFR Tie
  4. CEP-14083

CEP-14083 是一种与 ATP 竞争的 ALK 激酶抑制剂，其在酶学实验中的 IC50 值为 2 nM。CEP-14083 还抑制其他激酶，例如胰岛素受体 (IR)，血管内皮生长因子受体2 (VEGFR2)，血管生成素-1 受体 (TIE2) 和双亮氨酸拉链激酶 (DLK)。CEP-14083 抑制 CD274 mRNA 的表达以及在携带 NPM/ALK 的 T 细胞淋巴瘤 (ALK+TCL) 细胞中的 NPM/ALK 功能。CEP-14083 有望用于淋巴瘤的研究。

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CEP-14083 Chemical Structure

CEP-14083 Chemical Structure

CAS No. : 856692-39-2

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CEP-14083 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CEP-14083 is a ATP-competitive ALK kinase inhibitor with an IC50 value in enzymatic assays of 2 nM. CEP-14083 also inhibits other kinases, such as insulin receptor (IR), vascular endothelial growth factor receptor 2 (VEGFR2), angiopoietin-1 receptor (TIE2) and dual leucine zipper kinase (DLK). CEP-14083 suppresses CD274 mRNA expression and the NPM/ALK function in the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells. CEP-14083 is promising for research of lymphoma[1][2].

分子量

518.61

Formula

C31H30N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CEP-14083 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CEP-14083856692-39-2CEP14083CEP 14083Anaplastic lymphoma kinase (ALK)Insulin ReceptorVEGFRTieAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Vascular endothelial growth factor receptorAngiopoietin receptorATP-competitiveALKIRVEGFR2TIE2DLKCD274 expressionT cell lymphomaInhibitorinhibitorinhibit

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产品名称：
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目录号：
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