2. Cell Cycle/DNA Damage Cytoskeleton
  3. Mps1
  4. CFI-400936

CFI-400936 是一种有效的 TTK 抑制剂，IC50 为 3.6 nM。CFI-400936 具有抗肿瘤活性。

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CFI-400936 Chemical Structure

CFI-400936 Chemical Structure

CAS No. : 1338793-07-9

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CFI-400936 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CFI-400936 is a potent TTK inhibitor with an IC50 of 3.6 nM. CFI-400936 has antitumor activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
0.16 μM
Compound: 72, CFI-400936
Growth inhibition of human A549 cells after 5 days by SRB assay
Growth inhibition of human A549 cells after 5 days by SRB assay
[PMID: 25043312]
HCT-116 GI50
0.1 μM
Compound: 72, CFI-400936
Growth inhibition of human HCT116 cells after 5 days by SRB assay
Growth inhibition of human HCT116 cells after 5 days by SRB assay
[PMID: 25043312]
HCT-116 EC50
0.52 μM
Compound: 72, CFI-400936
Inhibition of TTK in human HCT116 cells assessed as phosphorylation of histone H3 at Ser10 residue after 4 hrs by immunoassay
Inhibition of TTK in human HCT116 cells assessed as phosphorylation of histone H3 at Ser10 residue after 4 hrs by immunoassay
[PMID: 25043312]
MDA-MB-468 GI50
0.66 μM
Compound: 72, CFI-400936
Growth inhibition of human MDA-MB-468 cells after 5 days by SRB assay
Growth inhibition of human MDA-MB-468 cells after 5 days by SRB assay
[PMID: 25043312]
分子量

477.58

Formula

C25H27N5O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CFI-400936 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFI-4009361338793-07-9CFI400936CFI 400936Mps1Monopolar spindle 1TTKInhibitorantitumorinhibitorinhibit

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产品名称：
CFI-400936
目录号：
HY-123675
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