2. Immunology/Inflammation
  3. Cyclic GMP-AMP Synthase
  4. cGAS-IN-3

cGAS-IN-3 (compound 30d-S) 是口服有效的环 GMP-AMP 合酶 (Cyclic GMP-AMP Synthase/cGAS) 抑制剂，具有良好的血浆暴露、低清除率。cGAS-IN-3 具有抗炎活性，在大鼠中可显着减轻肺部炎症[1].br/

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cGAS-IN-3 Chemical Structure

cGAS-IN-3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

cGAS-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

cGAS-IN-3 (compound 30d-S) is an orally active cyclic GMP-AMP synthase (Cyclic GMP-AMP Synthase/cGAS) inhibitor with good plasma exposure and low clearance. cGAS-IN-3 has anti-inflammatory activity and can significantly reduce lung inflammation in rats[1].

IC50 & Target

cGAS[1]
体外研究
(In Vitro)

cGAS-IN-3 在小鼠 RAW-Lucia 细胞中对 cGAS 的抑制效力 (IC50) 为 2.87 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

cGAS-IN-3 相关抗体:
体内研究
(In Vivo)

cGAS-IN-3 (30 mg/kg; po; 单剂量) 对 LPS 诱导的急性肺损伤 (ALI) 小鼠模型具有预防作用，可有效减轻炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced acute lung injury (ALI) mice model[1]
Dosage: 30 mg/kg
Administration: po; single dose and 0.5 h prior to ALI modeling; while ALI was induced by intratracheal instillation of 2 mg/kg LPS
Result: Alleviated the severity of lung injury, presented by the ameliorated pathological changes
Relieved pulmonary edema, and the reduced number of immune cells in BALF.
分子量

469.31

Formula

C21H20Cl2F2N4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

cGAS-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cGAS-IN-3Cyclic GMP-AMP SynthasecGASInhibitorinhibitorinhibit

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产品名称：
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目录号：
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