2. Metabolic Enzyme/Protease
  3. MMP
  4. CGS 27023A

CGS 27023A 是一种非肽类、具有口服活性的 MMP 抑制剂，对 MMP-3、MMP-1、MMP-2 和 MMP-9 的 Ki 值分别为 43、33、20 和 8 nM。CGS 27023A 可用于关节炎的研究。

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CGS 27023A Chemical Structure

CGS 27023A Chemical Structure

CAS No. : 169799-04-6

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CGS 27023A 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis[1].

IC50 & Target

stromelysins 1

43 nM (Ki)

collagenases 1

33 nM (Ki)

MMP-2

20 nM (Ki)

MMP-9

8 nM (Ki)

体内研究
(In Vivo)

CGS 27023A (75 µmol/kg，灌胃10 h) 对溶基质素诱导的兔软骨降解模型有抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

429.92

Formula

C18H24ClN3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CGS 27023A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGS 27023A169799-04-6MMPMatrix metalloproteinasesstromelysin-induced cartilage degradationarthritisInhibitorinhibitorinhibit

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产品名称：
CGS 27023A
目录号：
HY-18694
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