2. Metabolic Enzyme/Protease
  3. MMP
  4. CGS 27023A

CGS 27023A 是一种非肽类、具有口服活性的 MMP 抑制剂，对 MMP-3、MMP-1、MMP-2 和 MMP-9 的 Ki 值分别为 43、33、20 和 8 nM。CGS 27023A 可用于关节炎的研究。

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CGS 27023A Chemical Structure

CGS 27023A Chemical Structure

CAS No. : 169799-04-6

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CGS 27023A 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis[1].

IC50 & Target

stromelysins 1

43 nM (Ki)

collagenases 1

33 nM (Ki)

MMP-2

20 nM (Ki)

MMP-9

8 nM (Ki)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
3000 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
[PMID: 20180536]
MCF7 IC50
6900 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of constitutive sALCAM release by ELISA
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of constitutive sALCAM release by ELISA
[PMID: 20180536]
MCF7 IC50
750 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISA
Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISA
[PMID: 20180536]
MDA-MB-468 IC50
10000 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISA
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISA
[PMID: 20180536]
MDA-MB-468 IC50
1400 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of constitutive sALCAM release by ELISA
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of constitutive sALCAM release by ELISA
[PMID: 20180536]
MDA-MB-468 IC50
750 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
[PMID: 20180536]
SK-OV-3 IC50
110 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of EGF-induced sALCAM release by ELISA
[PMID: 20180536]
SK-OV-3 IC50
13000 nM
Compound: 1, CGS-27023A
Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of constitutive sALCAM release by ELISA
Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of constitutive sALCAM release by ELISA
[PMID: 20180536]
体内研究
(In Vivo)

CGS 27023A (75 µmol/kg，灌胃10 h) 对溶基质素诱导的兔软骨降解模型有抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

429.92

Formula

C18H24ClN3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CGS 27023A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGS 27023A169799-04-6MMPMatrix metalloproteinasesstromelysin-induced cartilage degradationarthritisInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
CGS 27023A
目录号：
HY-18694
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