Chitosan (≥95% deacetylated,viscosity 100-200 mPa.s)  (Synonyms: 壳聚糖 (脱乙酰度≥95%,粘度100-200 mPa.s); Deacetylated chitin (≥95% deacetylated,viscosity 100-200 mPa.s); Poly(D-glucosamine) (≥95% deacetylated,viscosity 100-200 mPa.s))

Chitosan (Deacetylated chitin) (≥95% deacetylated,viscosity 100-200 mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi^[1][2].

低分子量壳聚糖可以穿透细菌细胞壁，与 DNA 结合并抑制DNA转录和mRNA合成，而高分子量的壳聚糖可以与细菌细胞壁上的负电荷成分结合。它在细胞周围形成一个不透水层，改变细胞通透性并阻断向细胞内的运输。Chitosan还可用于水处理、伤口愈合材料、药物赋形剂或药物载体、肥胖症研究以及作为组织工程支架^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

在 ICR 小鼠的化学诱导的结肠癌前病变中，在为期 2 周的预防性实验中，喂食含有高分子量壳聚糖 (HMWC) 的饮食的小鼠与喂食对照饮食的小鼠相比，异常隐窝病灶形成明显减少。随着处理延长至 6 周，与对照组相比，低分子量壳聚糖 (LMWC) 和 HMWC 喂养的小鼠都含有较少的异常隐窝病灶^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

9012-76-4

固体

Off-white to light yellow

壳聚糖 (脱乙酰度≥95%,粘度100-200 mPa.s)； 脱乙酰壳多糖 (脱乙酰度≥95%,粘度100-200 mPa.s)； 甲壳素 (脱乙酰度≥95%,粘度100-200 mPa.s)

Room temperature in continental US; may vary elsewhere.

• [1]. Randy Chi Fai Cheung, et al. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications. Mar Drugs. 2015 Aug 14;13(8):5156-86.  [Content Brief]

  [2]. Shyr-Yi Lin, et al. Chitosan prevents the development of AOM-induced aberrant crypt foci in mice and suppressed the proliferation of AGS cells by inhibiting DNA synthesis. J Cell Biochem. 2007 Apr 15;100(6):1573-80.  [Content Brief]