2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway
  3. Bcr-Abl Src p38 MAPK
  4. CHMFL-ABL-053

CHMFL-ABL-053 (Compound 18a) 是一种有效的、选择性的、具有口服活性的 BCR-ABL、SRC 和 p38激酶抑制剂，IC50 值分别为 70、90 和 62 nM。

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CHMFL-ABL-053 Chemical Structure

CHMFL-ABL-053 Chemical Structure

CAS No. : 1808287-83-3

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规格 是否有货
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Customer Review

CHMFL-ABL-053 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

查看所有亚型
Lck Fyn Blk

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC50 values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively[1].

IC50 & Target

Abl

70 nM (IC50)

p38

62 nM (IC50)

SRC

90 nM (IC50)

体外研究
(In Vitro)

CHMFL-ABL-053 (Compound 18a) inhibits the proliferation of CML cell lines with GI50 of 14, 25 and 16 nM against K562, KU812 and MEG-01, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHMFL-ABL-053 相关抗体:
体内研究
(In Vivo)

CHMFL-ABL-053 (Compound 18a) (50 mg/kg/day) almost completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

549.55

Formula

C28H26F3N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CHMFL-ABL-053 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHMFL-ABL-0531808287-83-3Bcr-AblSrcp38 MAPKchronic myeloid leukemiaK562KU812MEG-01Inhibitorinhibitorinhibit

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产品名称：
CHMFL-ABL-053
目录号：
HY-101268
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