2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Chrexanthomycin C

Chrexanthomycin C 是一种具有显著生物活性的海洋天然产物，具有口服活性。Chrexanthomycin C 对 DNA (G4C2)4 G4 具有结合亲和力，Kd 值为 2.8 mM。Chrexanthomycin C 可用于肌萎缩侧索硬化症 (ALS) 等神经退行性疾病的研究。

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Chrexanthomycin C Chemical Structure

Chrexanthomycin C Chemical Structure

CAS No. : 3030587-55-1

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Chrexanthomycin C 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chrexanthomycin C is an orally active marine natural product with remarkable bioactivities. Chrexanthomycin C has binding affinity for DNA (G4C2)4 G4 with a Kd value of 2.8 mM. Chrexanthomycin C can be used for the research of neurodegenerative disease such as amyotrophic lateral sclerosis (ALS)[1].

IC50 & Target

Kd: 2.8 mM (DNA (G4C2)4 G4)[1]
体外研究
(In Vitro)

Chrexanthomycin C (Compounds cC) (0.1-10 mM) binds DNA (G4C2)4 G4 with a Kd value of 2.8 mM[1].
Chrexanthomycin C has good permeability, low cytotoxicity, and nonhemolytic activity[1].
Chrexanthomycin C (1.57 μM) rescues G4C2 EHR-related pathologies in cells[1].
Chrexanthomycin C selectively binds to DNA and RNA G4C2 G4s[1].
Chrexanthomycin C (0-100 μM) dramatically reduceS G4C2 EHR-caused cell death, diminish G4C2 RNA foci in (G4C2)29-expressing Neuro2a cells, and significantly eliminate ROS in HT22 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chrexanthomycin C 相关抗体:

Cell Viability Assay[1]

Cell Line: HEK293T cells
Concentration: 0.16, 1.57 and 15.67 μM
Incubation Time: 24 h
Result: Showed no cytotoxicity up to the concentration of 10 μg/mL.
体内研究
(In Vivo)

Chrexanthomycin C (Compounds cC) (fed; 100 μM) significantly rescues eye degeneration and improve locomotor deficits in (G4C2)29-expressing[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Drosophila[1]
Dosage: 100 μM
Administration: fed
Result: Rescued G4C2 EHR-Related Pathologies in Drosophila.
分子量

638.53

Formula

C31H26O15
CAS 号
结构分类
初始来源

Streptomyces chrestomyceticus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chrexanthomycin C 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chrexanthomycin C3030587-55-1DNA/RNA SynthesisG-quadruplex (G4)C9orf72 GGGGCC (G4C2)expanded hexanucleotide repeat (EHR)amyotrophic lateral sclerosis (ALS)frontotemporal dementia (FTD)neurodegenerative diseaseInhibitorinhibitorinhibit

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