Ciclopirox olamine  (Synonyms: Ciclopirox ethanolamine; HOE 296)

Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic^[1].

在一项为进一步阐明 Ciclopirox GMP 的机制而进行的研究中，筛选和测试了几种酿酒酵母突变体。对药物处理和突变影响的解释结果表明，Ciclopirox GMP 可能通过破坏 DNA 修复、细胞分裂信号和结构 (有丝分裂纺锤体) 以及细胞内运输的一些要素发挥作用^[2]。
Ciclopirox GMP 是一种广谱抗真菌药，具有抗炎特性，可有效对抗与脂溢性皮炎有关的酵母菌 Malassezia spp^[3]。
Ciclopirox (olamine) (0.9 μM, 24 h) 保护暴露于 TBHP 诱导的人类 iPSC 衍生 RPE 细胞免受氧化损伤^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

268.35

C₁₄H₂₄N₂O₃

41621-49-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Niewerth M, et al. Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. Antimicrob Agents Chemother. 2003 Jun;47(6):1805-17.  [Content Brief]

  [2]. Cai H, et al. High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMD. Exp Eye Res. 2019 Aug;185:107641.  [Content Brief]