Citalopram-d₃ hydrochloride  (Synonyms: 西酞普兰盐酸盐-d₃)

Citalopram-d₃ hydrochloride is deuterated labeled Citalopram (HY-121203). Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission^[1][2][3].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
Citalopram (25-175 μM；24 小时) 显示出浓度依赖性细胞毒性^[4]。
Citalopram (100 μM；24 小时) 强烈下调 B104 细胞中的 MYBL2、BIRC5、BARD1、AURKA、CCNA2 和 CCNE1^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Citalopram (5-40mg/kg；腹腔注射) 可减少 DBA/2J 小鼠的不动时间，但不会减少 C57BL/6J 小鼠^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

363.87

C₂₀H₁₉D₃ClFN₂O

59729-33-8

西酞普兰盐酸盐-d₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Carlsson B, et al. Enantioselective analysis of citalopram and escitalopram in postmortem blood together with genotyping for CYP2D6 and CYP2C19. J Anal Toxicol. 2009;33(2):65-76.  [Content Brief]

  [3]. Laurent Sakka, et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8(26):42789-42807.  [Content Brief]

  [4]. Milne RJ, et al. Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs. 1991;41(3):450-477.  [Content Brief]

  [5]. Zeng-Liang Jin, et al. Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function. Sci Rep. 2017 Aug 17;7(1):8631.  [Content Brief]