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  4. CJ-15208

CJ-15208是一种强效和选择性的κ-阿片受体拮抗剂，具有显著的阿片活性。CJ-15208在小鼠的温水尾撤回实验中表现出强烈的镇痛效果，并且通过多个阿片受体介导。CJ-15208的立体异构体展现出不同的阿片活性特征，例如一种立体异构体表现出κ-阿片受体拮抗作用，而另一种则表现出δ-阿片受体拮抗作用。CJ-15208的所有立体异构体在呼吸方面没有显著的影响。CJ-15208的立体异构体未导致耐药性的发展，这使其在进一步研发安全的阿片类镇痛药方面具有潜力。

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CJ-15208 Chemical Structure

CJ-15208 Chemical Structure

CAS No. : 210236-47-8

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CJ-15208 相关抗体

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  • 生物活性

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生物活性

CJ-15208 is a potent and selective κ-opioid receptor antagonist with significant opioid activity. CJ-15208 exhibited strong analgesic effects in the warm water tail withdrawal test in mice and was mediated through multiple opioid receptors. The stereoisomers of CJ-15208 exhibited different opioid activity characteristics, for example, one stereoisomer exhibited κ-opioid receptor antagonism, while the other exhibited δ-opioid receptor antagonism. All stereoisomers of CJ-15208 had no significant effects on respiration. The stereoisomers of CJ-15208 did not lead to the development of drug tolerance, which makes it potential in the further development of safe opioid analgesics[1].

分子量

577.67

Formula

C34H35N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CJ-15208 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

CJ-15208210236-47-8CJ15208CJ 15208OthersInhibitorinhibitorinhibit

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产品名称：
CJ-15208
目录号：
HY-117881
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