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Clofibride  (Synonyms: 氯贝胺)

目录号: HY-119524
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摩尔计算器

Clofibride 是一种对氯苯氧基异丁酸型降脂剂，具有口服活性。Clofibride 具有弱毒性和显著的降胆固醇和降甘油三酯活性。Clofibride 在体内可转化为 4-氯苯氧基异丁酸 (CPIB) 和 4-羟基-N-二甲基丁酰胺 (HMB)。

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Clofibride Chemical Structure

Clofibride Chemical Structure

CAS No. : 26717-47-5

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Clofibride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Clofibride is an orally active hypolipaemic agent of pchlorophenoxyisobutyric type. Clofibride has weak toxicity and marked hypocholesterolaemic and hypotriglyceridaemic activity. Clofibride is converted into 4-chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) in vivo[1].

体内研究
(In Vivo)

Clofibride (oral, 400; 500 and 1000 mg/kg; single) can rapidly and massively resorb and hydrolys into 4chlorophenoxyisobutyric acid (CPIB) and 4-hydroxy-N-dimethylbutyramide (HMB) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD rats, male and female beagles, olive baboon monkeys[1]
Dosage: 400, 1000 mg/kg (rats); 500 mg/kg (dogs and monkeys)
Administration: oral, single
Result: HMB is rapidly metabolized and the half-life of CPIB, the main active metabolite, in the serum is about 12 h in the rat, 43 +9 h in the dog and 6t 1 h in the baboon.
分子量

327.80

Formula

C16H22ClNO4
CAS 号
中文名称

氯贝胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Clofibride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

Clofibride26717-47-5氯贝胺Othersoralhypolipaemicpchlorophenoxyisobutyrichypocholesterolaemichypotriglyceridaemic4-chlorophenoxyisobutyric acid (CPIB)4-hydroxy-N-dimethylbutyramide (HMB)Inhibitorinhibitorinhibit

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