2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Anti-infection
  3. Reactive Oxygen Species Influenza Virus
  4. Cobalt protoporphyrin IX

Cobalt protoporphyrin IX  (Synonyms: Co-PPIX)

目录号: HY-134608
产品使用指南

摩尔计算器

Cobalt protoporphyrin IX (Co-PPIX) 是一种有效的特异性血红素加氧酶-1 (HO-1) 诱导剂。Cobalt protoporphyrin IX 对甲型流感病毒 (IAV) 具有广谱抗病毒活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cobalt protoporphyrin IX Chemical Structure

Cobalt protoporphyrin IX Chemical Structure

CAS No. : 14325-03-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Cobalt protoporphyrin IX 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV)[1].

体外研究
(In Vitro)

Cobalt protoporphyrin IX (2 μM; 0-24 h) 在 MDCK 细胞和 RAW264.7 细胞中以时间依赖的方式增加 HO-1 细胞内蛋白水平[1]。
Cobalt protoporphyrin IX 对 Empty Cell A/FortMonmouth /1/1947、A/TianjinJinnan /15/2009、A/Wuhan /359/1995、A/FujianTongan /196/2009 和 BY/FujianXinluo /54/2006 流感病毒的 IC50分别为 0.40 ± 0.16、0.42 ± 0.15、0.46 ± 0.19、0.34 ± 0.05 和 0.64 ± 0.30 μM[1]。
Cobalt protoporphyrin IX (0.25-2 μM; 18 or 24 h) 通过增强 IFN 反应抑制 IAV 复制，抗 IAV 活性不依赖于 HO-1 的催化功能[1]。
Cobalt protoporphyrin IX (2 μM; 0-6 h) 诱导 HO-1 抗 IAV 活性可能依赖于 IRF3 磷酸化和易位，以增强抗病毒 IFN 应答[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cobalt protoporphyrin IX 相关抗体:

Western Blot Analysis[1]

Cell Line: MDCK cells and RAW264.7 cells
Concentration: 2 μM
Incubation Time: 0, 3, 6, 12 and 24 h
Result: Significantly increased the intracellular protein levels of HO-1 in a time-dependent manner in MDCK cells and RAW264.7 cells.

Real Time qPCR[1]

Cell Line: RAW264.7 cells were infected with IAV A/Fort Monmouth/1/1947 (0.2 MOI)
Concentration: 0.25, 0.5, 1 and 2 μM
Incubation Time: 18 h
Result: Enhanced mRNA expressions of IFN-α/β, as well as protein expressions of some ISGs, such as IFN-inducible transmembrane protein 3 (IFITM3), double-stranded RNA-dependent protein kinase (PKR) and 2′-5′-oligoadenylate synthetase 1 (OAS1), in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: RAW264.7 cells or RAW264.7 cells infected with IAV A/Fort Monmouth/1/1947 (0.2 MOI)
Concentration: 2 μM
Incubation Time: 0, 2, 4 and 6 h
Result: Increased protein levels of IRF3 and p-IRF3. Promoted the cytoplasmic protein levels of IRF3 and p-IRF3 in RAW264.7 cells following the enhancement of HO-1 protein expression after 6 h. Induced nuclear IRF3 and nuclear p-IRF3 accumulation within 6 h of treatment.
分子量

619.58

Formula

C34H32CoN4O4
CAS 号
性状

固体

颜色

Brown to black

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Cobalt protoporphyrin IX 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cobalt protoporphyrin IX14325-03-2Co-PPIXReactive Oxygen SpeciesInfluenza VirusMDCKRAW264.7Empty Cell A/FortMonmouth /1/1947A/TianjinJinnan /15/2009A/Wuhan /359/1995A/FujianTongan /196/2009BY/FujianXinluo /54/2006Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Cobalt protoporphyrin IX
目录号：
HY-134608
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z