2. Apoptosis
  3. Apoptosis
  4. Conophylline

Conophylline  (Synonyms: 长春花碱)

目录号: HY-N3619 纯度: ≥98.0%
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Conophylline 是一种从热带植物 Ervatamia microphylla 中提取的长春花生物碱。Conophylline 是胰腺细胞分化的诱导剂。Conophylline 能抑制 HSC，诱导其凋亡。

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Conophylline Chemical Structure

Conophylline Chemical Structure

CAS No. : 142741-24-0

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Conophylline 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis[1][2].

体外研究
(In Vitro)

Conophylline (100 ng/mL；48 hours) 重现激活素的分化诱导活性而不是细胞凋亡诱导活性[1]。
Conophylline (100 ng/mL；72 hours) 表现出分化-诱导 AR42J 细胞活性，并将这些细胞转化为内分泌细胞[1]。
Conophylline 通过激活 p38 丝裂原活化蛋白激酶增加 neurogenin-3 的表达，从而诱导 AR42J 细胞分化[1]。
Conophylline 降低大鼠 HSC 和 Lx-2 细胞 α-SMA 和 collagen-1 的表达[2]。
Conophylline 抑制血清诱导的 DNA 合成[2]。
Conophylline 还促进 caspase-3 的活化并诱导 Lx-2 细胞凋亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Conophylline 相关抗体:

Apoptosis Analysis[2]

Cell Line: Lx-2 Cells
Concentration: 12 hours
Incubation Time: 0.1 μg/ml
Result: Induced apoptosis

Western Blot Analysis[2]

Cell Line: Lx-2 cells
Concentration: 0.1 μg/ml
Incubation Time: 15 minutes, 30 minutes, 60 minutes, 120 minutes
Result: Increased phospho-JNK.
体内研究
(In Vivo)

Conophylline (0.9 mg/kg；口服；每日一次；持续 12 周) 在体内减轻 TAA 诱导的肝纤维化形成[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (70-80 g)[2]
Dosage: 0.9 mg/kg
Administration: Oral administration; daily; for 12 weeks
Result: Attenuated formation of the liver fibrosis induced by TAA.
分子量

794.89

Formula

C44H50N4O10
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

长春花碱
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (277 KB)

产品使用指南 (1538 KB)
参考文献

Conophylline 相关分类

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Keywords:

Conophylline142741-24-0长春花碱ApoptosisDifferentiationinducerpancreaticHSCInhibitorinhibitorinhibit

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