2. Apoptosis
  3. MDM-2/p53 Apoptosis
  4. CP-31398

CP-31398 可在 p53 突变或野生型的癌细胞中，稳定 p53 的活性构象，促进 p53 的活性。此外，CP-31398 可上调 p53 目标基因，如 p21WAF1/Cip1 和 KILLER/DR5。CP-31398 具有抑制肿瘤生长的作用。

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CP-31398 Chemical Structure

CP-31398 Chemical Structure

CAS No. : 259199-65-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

CP-31398 的其他形式现货产品:

Customer Review

Other Forms of CP-31398:

CP-31398 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP-31398 can stabilize the active conformation of p53 and promote p53 activity in cancer cells with either mutant or wild-type p53. In addition, CP-31398 can upregulate p53 target genes, such as p21WAF1/Cip1 and KILLER/DR5. CP-31398 exerts an inhibitory effect on tumor growth[1][2][3].

体外研究
(In Vitro)

CP-31398 (36.75 μM，16 小时) 可在 p53 突变细胞中诱导 p21 的表达[1]。
CP-31398 (15 μg/mL，20 小时) 可在 SW480 细胞中诱导凋亡和细胞周期停滞[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CP-31398 相关抗体:

Western Blot Analysis[1]

Cell Line: Saos-2 cells expressing transfected mutant p53
Concentration: 36.75 μM
Incubation Time: 16 h
Result: Induction of p21 in cells expressing only mutant p53.

Western Blot Analysis[3]

Cell Line: LN-18 and U87MG cells
Concentration: 36 μM
Incubation Time: 16 h
Result: Decreased the levels of procaspase 3 and induced cleavage of caspase 7.
体内研究
(In Vivo)

CP-31398 (100 mg/kg，口服，每天两次，共 7 天) 在异种移植小鼠模型中表现出显著的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Small human tumor xenografts in mice[1]
Dosage: 100 mg/kg
Administration: Orally twice daily for 7 days
Result: Suppressed A375.S2 tumor growth by -50%.
分子量

362.47

Formula

C22H26N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CP-31398 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-31398259199-65-0CP31398CP 31398MDM-2/p53ApoptosisSmall human tumor xenograftsSaos-2 cellsLN-18 and U87MG cellsAnti-tumorInhibitorinhibitorinhibit

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