2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis
  4. CPT-Se4

CPT-Se4 是喜树碱 (CPT) 的一种含硒前体活性分子，在杀死癌细胞和抑制肿瘤生长方面表现出更高的效力。CPT-Se4 降低 GSH/GSSG 比率和总硫醇，提高 Hep G2 细胞中的 ROS 水平，并最终诱导癌细胞凋亡 (apoptosis)。CPT-Se4 对 HeLa、Hep G2、A549 和 SMMC-7721 细胞具有细胞毒性（IC50=2.54-6.4 μM）。

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CPT-Se4 Chemical Structure

CPT-Se4 Chemical Structure

CAS No. : 2968315-03-7

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CPT-Se4 相关抗体

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CPT-Se4, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT-Se4 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se4 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC50= 2.54-6.4 μM)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3.3 μM
Compound: CPT-Se4
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34852457]
HeLa IC50
2.56 μM
Compound: CPT-Se4
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34852457]
HepG2 IC50
2.54 μM
Compound: CPT-Se4
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34852457]
SMMC-7721 IC50
6.4 μM
Compound: CPT-Se4
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 34852457]
分子量

622.39

Formula

C25H24N2O7Se2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CPT-Se4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPT-Se42968315-03-7TopoisomeraseApoptosisHeLaHep G2A549SMMC-7721 cellsROSCPTprodrugInhibitorinhibitorinhibit

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目录号：
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