2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. CPUY201112

CPUY201112 是一种有效的热休克蛋白 Hsp90 抑制剂，其 Kd 值为27 nM。CPUY201112 可诱导 p53 介导的 MCF-7 细胞凋亡，使细胞周期停滞，可用于癌症研究。

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CPUY201112 Chemical Structure

CPUY201112 Chemical Structure

CAS No. : 1860793-58-3

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CPUY201112 相关抗体

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查看 HSP 亚型特异性产品:

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
0.76 μM
Compound: 50
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 27933959]
MCF7 IC50
0.62 μM
Compound: 50
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 27933959]
体外研究
(In Vitro)

CPUY201112 (0-9 μM, 7 days) 以剂量依赖的方式降低多种癌细胞系的活力, 如 HCT116 结肠细胞、HepG2 肝细胞癌和其他癌细胞[1]。
CPUY201112 (0-2 μM, 24 h) 可以剂量依赖性诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CPUY201112 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HCT116, HepG2, MCF-7, A549
Concentration: 0-9 μM
Incubation Time: 7 days
Result: Inhibited MCF-7, A549, HCT116 and HepG2 cells with the IC50 values of 0.624, 0.543, 0.763 and 0.342 μM, respectively.

Apoptosis Analysis[1]

Cell Line: MCF-7 and HCT116 cells
Concentration: 0-2 μM
Incubation Time: 24 h
Result: Induced cell cycle arrest in G2/M phase and induced apoptosis in more than 35% of MCF-7 cells.
Induced p53-mediated apoptosis in HCT116 cells.
体内研究
(In Vivo)

CPUY201112 (5-40 mg/kg, i.p., daily, 3 weeks) 在 MCF-7 肿瘤异种移植模型中抑制了肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice with MCF-7 cell[1]
Dosage: 5 mg/kg, 20 mg/kg and 40 mg/kg
Administration: i.p., daily, 3 weeks
Result: Reduced tumor volume by 11.92%, 26.58% and 39.63%, respectively, when using 5 mg/kg, 20 mg/kg and 40 mg/kg.
Significantly induced the expression of Hsp70 and reduced the expression of Akt at 40 mg/kg.
分子量

357.40

Formula

C19H23N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CPUY201112 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPUY2011121860793-58-3CPUY 201112CPUY-201112HSPApoptosisHeat shock proteinsHsp90p53apoptosiscell cyclecancerInhibitorinhibitorinhibit

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HY-111524
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