2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. CYY292

CYY292 是 FGFR1 抑制剂，能够特异性靶向 GBM 细胞中的 FGFR1/AKT/Snail 通路。CYY292 在体外剂量依赖性地抑制癌细胞增殖、上皮间质转化、干细胞性、侵袭和迁移。

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CYY292 Chemical Structure

CYY292 Chemical Structure

CAS No. : 2644673-04-9

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规格 价格 是否有货 数量
5 mg ￥2200
3 - 5 周
10 mg ￥3500
3 - 5 周
25 mg 现货 3 - 5 周
50 mg   询价  
100 mg   询价  

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Customer Review

CYY292 相关抗体

Top Publications Citing Use of Products

查看 FGFR 亚型特异性产品:

查看所有亚型
FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CYY292 is an FGFR1 inhibitor that specifically targets the FGFR1/AKT/Snail pathway in GBM cells. CYY292 dose-dependently inhibits cancer cell proliferation, epithelial-mesenchymal transition, stemness, invasion, and migration in vitro[1].

IC50 & Target

FGFR1[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HOS-TE85 IC50
1.36 μM
Compound: 7l
Antiproliferative activity against human MNNG/HOS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MNNG/HOS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 35239349]
MG-63 IC50
0.84 μM
Compound: 7l
Antiproliferative activity against human MG-63 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MG-63 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 35239349]
SAOS-2 IC50
0.72 μM
Compound: 7l
Antiproliferative activity against human SAOS-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SAOS-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 35239349]
U2OS IC50
0.76 μM
Compound: 7l
Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 35239349]
分子量

444.53

Formula

C24H28N8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CYY292 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYY2922644673-04-9CYY 292CYY-292FGFRFibroblast growth factor receptorCell proliferationepithelial-mesenchymal transitionstem cell invasioncell migrationInhibitorinhibitorinhibit

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产品名称：
CYY292
目录号：
HY-162153
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