Dapoxetine  (Synonyms: 达泊西汀; (S)-(+)-Dapoxetine; LY-210448)

Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)^[1].

Dapoxetine binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine≫dopamine.
Dapoxetine inhibits the uptake of [³H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [³H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [³H]dopamine by the dopamine reuptake transporter with IC₅₀ values of 202 nM and 1720 nM, respectively.^[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dapoxetine (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

305.41

C₂₁H₂₃NO

119356-77-3

达泊西汀

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Muammer Kendirci, et al. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag. 2007 Jun;3(2):277-89.  [Content Brief]

  [2]. Rabab H Sayed, et al. Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol. 2016 Nov 15;311:52-60.  [Content Brief]