2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Darexaban maleate

Darexaban maleate  (Synonyms: YM150 maleate)

目录号: HY-135541
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摩尔计算器

Darexaban maleate (YM150 maleate)是一种直接因子Xa抑制剂，具有预防静脉血栓栓塞的活性。Darexaban maleate在人体内的主要代谢产物为Darexaban葡萄糖醇，作用于药理学。Darexaban maleate的葡萄糖醇化反应主要由UGT1A9和UGT1A10在人体肝脏和肠道中催化。Darexaban maleate在肝脏的葡萄糖醇化K(m)值大于250 μM，而在肠道中则呈现底物抑制动力学，K(m)值为27.3 μM。Darexaban maleate的无结合K(m)值在HLM和UGT1A9中都受到了脂肪酸游离牛血清白蛋白的影响而显著降低。

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Darexaban maleate Chemical Structure

Darexaban maleate Chemical Structure

CAS No. : 365462-24-4

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Darexaban maleate 相关抗体

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生物活性

Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serum albumin in both HLM and UGT1A9[1].

分子量

590.62

Formula

C31H34N4O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Darexaban maleate 相关分类

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Keywords:

Darexaban365462-24-4YM150YM 150YM-150Endogenous MetaboliteInhibitorinhibitorinhibit

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