2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. DBCO-NHCO-PEG4-amine

DBCO-NHCO-PEG4-amine 是一种 PROTAC 连接桥，属于 PEG 类。DBCO-NHCO-PEG4-amine 是一种可降解 (cleavable) 的 ADC linker，可用于连接 MMAE (HY-15162) 和抗体 (例如 DBCO-VCpAB−MMAE 和 DBCO-TRX−MMAE，对 SKBR3 细胞的 EC50 分别为 280 nM 和 22 nM)。

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DBCO-NHCO-PEG4-amine Chemical Structure

DBCO-NHCO-PEG4-amine Chemical Structure

CAS No. : 1255942-08-5

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DBCO-NHCO-PEG4-amine 相关抗体

Top Publications Citing Use of Products

查看 ADC Linker 亚型特异性产品:

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

查看 PROTAC Linkers 亚型特异性产品:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1].

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-NHCO-PEG4-amine 相关抗体:
分子量

523.62

Formula

C29H37N3O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DBCO-NHCO-PEG4-amine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-NHCO-PEG4-amine1255942-08-5ADC LinkerPROTAC LinkersAntibody-drug conjugates linkernon-cleavableADCantibody-drugconjugatesMMAEDBCO-VCpAB?MMAEDBCO-TRX?MMAESKBR3Inhibitorinhibitorinhibit

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目录号：
HY-124386
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