1. Immunology/Inflammation
  2. PSMA
  3. DCFBC

DCFBC 是一种前列腺特异性膜抗原(PSMA)抑制剂,可用于小型动物正电子发射断层扫描(PET)成像。DCFBC 经过 F18 标记 ([18F]DCFBC),对严重联合免疫缺陷小鼠成像时,[18F]DCFBC 在 PIP 肿瘤中摄取高,而在 FLU 肿瘤中几乎无摄取。[18F]DCFBC 在肾脏和膀胱中的吸收较高,但放射性洗脱时间比 PIP 肿瘤短。说明 [18F]DCFBC 能够特异性定位于表达 PSMA+ 的肿瘤,应用于前列腺癌的研究。

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DCFBC Chemical Structure

DCFBC Chemical Structure

CAS No. : 564482-79-7

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生物活性

DCFBC is a prostate-specific membrane antigen (PSMA) inhibitor that can be used for small animal positron emission tomography (PET) imaging. DCFBC labeled with F18 ([18F]DCFBC) can images in severe combined immunodeficient mice. [18F]DCFBC uptake is higher in PIP tumors, but almost absent in FLU tumors. [18F]DCFBC uptake is also high in the kidney and bladder, but the radioactivity washout time is shorter than that in PIP tumors. Indicating that [18F]DCFBC can specifically localize to PSMA+ expressing tumors and is applicable to the study of prostate cancer[1].

分子量

402.39

Formula

C16H19FN2O7S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
DCFBC
目录号:
HY-121659
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