2. MAPK/ERK Pathway
  3. Raf MEK
  4. Debromohymenialdisine

Debromohymenialdisine  (Synonyms: 10Z-Debromohymenialdisine)

目录号: HY-113632
产品使用指南 技术支持

Debromohymenialdisine (10Z-Debromohymenialdisine) 是一种吡咯生物碱。Debromohymenialdisine 在初始 Raf/MEK-1/MAPK 信号级联分析中具有中等抑制活性，IC50 值为 881 nM。Debromohymenialdisine 可用于增殖和分化的研究。

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Debromohymenialdisine Chemical Structure

Debromohymenialdisine Chemical Structure

CAS No. : 75593-17-8

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规格 是否有货
100 μg 询价

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Debromohymenialdisine 相关抗体

Top Publications Citing Use of Products

查看 Raf 亚型特异性产品:

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BRaf c-Raf Raf

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MEK1 MEK2 MEK5 MEK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC50 value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation[1].

IC50 & Target

IC50: 881 nM (in Raf/MEK-1/MAPK signaling cascade assay)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A498 ED50
24.7 μg/mL
Compound: 2
Cytotoxicity against human A498 cells by SRB assay
Cytotoxicity against human A498 cells by SRB assay
[PMID: 9051914]
KM-20L2 ED50
8.5 μg/mL
Compound: 2
Cytotoxicity against human KM20L2 cells by SRB assay
Cytotoxicity against human KM20L2 cells by SRB assay
[PMID: 9051914]
L5178Y EC50
1.8 μg/mL
Compound: 1d; DBH
Cytotoxicity against mouse L5178Y cells by MTT assay
Cytotoxicity against mouse L5178Y cells by MTT assay
[PMID: 33901899]
MONO-MAC-6 IC50
2.4 μg/mL
Compound: 5
Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs
Cytotoxicity against human MONO-MAC 6 cells assessed as [3H]thymidine incorporation after 48 hrs
[PMID: 9917317]
MONO-MAC-6 IC50
9.67 μM
Compound: 7
Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis
Cytotoxicity against human MONO-MAC-6 cells incubated for 48 hrs by [3H]-thymidine incorporation based liquid scintillation counter analysis
[PMID: 36496202]
NCI-H460 ED50
42 μg/mL
Compound: 2
Cytotoxicity against human H460 cells by SRB assay
Cytotoxicity against human H460 cells by SRB assay
[PMID: 9051914]
OVCAR-3 ED50
1.8 μg/mL
Compound: 2
Cytotoxicity against human OVCAR-3 cells by SRB assay
Cytotoxicity against human OVCAR-3 cells by SRB assay
[PMID: 9051914]
SF-295 ED50
38.9 μg/mL
Compound: 2
Cytotoxicity against human SF295 cells by SRB assay
Cytotoxicity against human SF295 cells by SRB assay
[PMID: 9051914]
SK-MEL-5 ED50
5.7 μg/mL
Compound: 2
Cytotoxicity against human SK-MEL-5 cells by SRB assay
Cytotoxicity against human SK-MEL-5 cells by SRB assay
[PMID: 9051914]
体外研究
(In Vitro)

Debromohymenialdisine has moderate inhibitory activity with an IC50 value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Debromohymenialdisine 相关抗体:
分子量

245.24

Formula

C11H11N5O2
CAS 号
结构分类
初始来源

Stylissa massa
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Debromohymenialdisine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Debromohymenialdisine75593-17-810Z-DebromohymenialdisineRafMEKRaf kinasesMitogen-activated protein kinase kinaseMAPKKMAP2Kpyrrole alkaloidRaf/MEK-1/MAPKsignalingproliferationdifferentiationInhibitorinhibitorinhibit

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