2. Apoptosis NF-κB
  3. Bcl-2 Family Keap1-Nrf2 Apoptosis
  4. Dehydrobruceine B

Dehydrobruceine B 是一种苦木素，可从鸦胆子 (Brucea javanica) 中分离得到。Dehydrobruceine B 与 Cisplatin (HY-17394) 通过线粒体途径，协同诱导细胞凋亡 (apoptosis)。Dehydrobruceine B 还增加凋亡诱导因子 (AIF) 和 Bax 表达，抑制 Keap1-Nrf2。

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Dehydrobruceine B Chemical Structure

Dehydrobruceine B Chemical Structure

CAS No. : 53730-90-8

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Dehydrobruceine B 相关抗体

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查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2[1].

IC50 & Target[1]

Bax

 

Bcl-xL

 

Bcl-2

 

体外研究
(In Vitro)

Dehydrobruceine B (1 μM; 48 h) 和 Cisplatin (3-18 μM; 48 h) 在 A549 细胞中具有协同作用，致使细胞毒性和凋亡效应[1]。
Dehydrobruceine B (1 μM; 24 h) 在 Cisplatin (3 μM, 6 μM; 24 h) 处理的A549细胞中，诱导胞内 ROS 产生[1]。
Dehydrobruceine B (3 μM, 6 μM; 24 h) 在 Cisplatin (3 μM, 6 μM; 24 h) 处理的A549细胞中，促进线粒体膜电位 (MMP) 的去极化和细胞色素 c 的易位[1]。
Dehydrobruceine B (1 μM; 24 h) 增强 A549 细胞抗凋亡和促凋亡蛋白水平的变化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dehydrobruceine B 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 1 μM; with or without Cisplatin
Incubation Time: 48 hours
Result: Upregulated the protein level of Bax, while downregulated the levels of Bcl-2 and Bcl-xL.
Enhanced caspase activation and PARP cleavage.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 1 μM; with or without Cisplatin
Incubation Time: 48 hours
Result: Inhibited cell viability with 9 μM and 18 μM Cisplatin, respectively.
Induced cell apoptosis with 3 μM and 6 μM Cisplatin, respectively.

Immunofluorescence[1]

Cell Line: A549 cells
Concentration: 1 μM; with or without 3 μM and 6 μM Cisplatin, respectively
Incubation Time: 24 hours
Result: Resulted apoptosis-inducing factor (AIF) translocated from cytosol into nucleus dramatically in the co-treatment condition.
分子量

478.45

Formula

C23H26O11
CAS 号
结构分类
初始来源

B. antidysenterica and B. guineensis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dehydrobruceine B 相关分类

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Keywords:

Dehydrobruceine B53730-90-8Bcl-2 FamilyKeap1-Nrf2ApoptosisInhibitorinhibitorinhibit

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