2. 天然产物
  3. 植物 酚类
  4. 忍冬科 多酚类
  5. 接骨木
  6. Demethylcarolignan E

Demethylcarolignan E  (Synonyms: Carolignan M)

目录号: HY-N7589
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摩尔计算器

Demethylcarolignan E 是一种苯丙素酯，可以从木槿花 (Hibiscus taiwanensi) 的茎中分离出来。Demethylcarolignan E 对人类癌细胞系 A549 和 MCF-7 具有细胞毒性 (IC50: <10 μg/mL)。

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Demethylcarolignan E Chemical Structure

Demethylcarolignan E Chemical Structure

CAS No. : 873694-46-3

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Demethylcarolignan E 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Demethylcarolignan E is a phenylpropanoid ester that can be isolated from the stems of Hibiscus taiwanensi. Demethylcarolignan E has cytotoxicity against human cancer lines A549 and MCF-7 (IC50: <10 μg/mL)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DLD-1 IC50
> 40 μM
Compound: 2
Cytotoxicity against human Wnt-dependent DLD1 cells after 24 hrs by fluorometric microculture cytotoxicity assay
Cytotoxicity against human Wnt-dependent DLD1 cells after 24 hrs by fluorometric microculture cytotoxicity assay
[PMID: 26026364]
HCT-116 IC50
> 39 μM
Compound: 2
Cytotoxicity against human Wnt-dependent HCT116 cells after 24 hrs by fluorometric microculture cytotoxicity assay
Cytotoxicity against human Wnt-dependent HCT116 cells after 24 hrs by fluorometric microculture cytotoxicity assay
[PMID: 26026364]
HEK293 IC50
24.2 μM
Compound: 2
Cytotoxicity against human HEK293 cells after 24 hrs by fluorometric microculture cytotoxicity assay
Cytotoxicity against human HEK293 cells after 24 hrs by fluorometric microculture cytotoxicity assay
[PMID: 26026364]
HEK293 IC50
4.5 μM
Compound: 2
Inhibition of Wnt/beta-catenin signaling in HEK293 cells stably transfected with TOP reporter gene assessed as TCF/beta-catenin transcriptional activity after 24 hrs by TOP activity/luciferase reporter gene assay
Inhibition of Wnt/beta-catenin signaling in HEK293 cells stably transfected with TOP reporter gene assessed as TCF/beta-catenin transcriptional activity after 24 hrs by TOP activity/luciferase reporter gene assay
[PMID: 26026364]
RKO IC50
23 μM
Compound: 2
Cytotoxicity against human Wnt-independent RKO cells after 24 hrs by fluorometric microculture cytotoxicity assay
Cytotoxicity against human Wnt-independent RKO cells after 24 hrs by fluorometric microculture cytotoxicity assay
[PMID: 26026364]
SW480 IC50
> 40 μM
Compound: 2
Cytotoxicity against human Wnt-dependent SW480 cells after 24 hrs by fluorometric microculture cytotoxicity assay
Cytotoxicity against human Wnt-dependent SW480 cells after 24 hrs by fluorometric microculture cytotoxicity assay
[PMID: 26026364]
分子量

716.73

Formula

C39H40O13
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Demethylcarolignan E 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Demethylcarolignan E873694-46-3Carolignan MOthersCytotoxicityA549MCF-7Hibiscus taiwanensiAnti-cancerInhibitorinhibitorinhibit

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