1. GPCR/G Protein
  2. Oxytocin Receptor
  3. Demoxytocin

Demoxytocin 是一种异源性环肽,是催产素类似物。Demoxytocin 影响细胞膜的通透性,增加平滑肌细胞中钙离子的含量,从而增加平滑肌细胞的收缩。Demoxytocin 也能刺激子宫平滑肌的收缩。Demoxytocin 具有催产素的功能。Demoxytocin 可用于研究早产破裂的分娩刺激。

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Custom Peptide Synthesis

Demoxytocin Chemical Structure

Demoxytocin Chemical Structure

CAS No. : 113-78-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Demoxytocin, a heterodetic cyclic peptide, is an analog of oxytocin. Demoxytocin affects the permeability of the cell membrane, increasing the content of calcium ions in smooth muscle cells, increasing its contraction. Demoxytocin also stimulates the contraction of smooth muscles of the uterus. Demoxytocin has the function of oxytocin. Demoxytocin can be used to research stimulation of labor in cases of premature rupture[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
0.04 nM
Compound: 16; [Mpa1]OT
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
[PMID: 27297999]
CHO-K1 EC50
0.1 nM
Compound: 3
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 IC50
> 10000 nM
Compound: 3
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 EC50
180 nM
Compound: 3
Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 EC50
21 nM
Compound: 3
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 EC50
3.5 nM
Compound: 3
Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
分子量

992.17

Formula

C43H65N11O12S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Demoxytocin
目录号:
HY-P2168
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