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Denagliptin  (Synonyms: GSK823093)

目录号: HY-167680
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Denagliptin (GSK823093)是一种小分子二肽酰肽酶IV（DPP-4）抑制剂，具有用于抑制内分泌和代谢疾病的活性。Denagliptin可用于研究2型糖尿病。Denagliptin在固态下稳定，但在溶液中及与各种赋形剂的混合物中降解。Denagliptin在胶囊中也表现出降解，主要通过环化反应形成(3S,7S,8aS)氨基脘提供进一步的合成物质。Denagliptin的降解途径被阐明，为其配方开发和监管文件支持提供了数据。

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Denagliptin Chemical Structure

Denagliptin Chemical Structure

CAS No. : 483369-58-0

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Denagliptin 相关抗体

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生物活性

Denagliptin (GSK823093) is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor with activity for the suppression of endocrine and metabolic diseases. Denagliptin can be used to study type 2 diabetes. Denagliptin is stable in the solid state but degrades in solution and in mixtures with various excipients. Denagliptin also exhibits degradation in capsules, mainly through cyclization reactions to form (3S,7S,8aS) aminoamines to provide further synthetic materials. The degradation pathway of Denagliptin was elucidated, providing data to support its formulation development and regulatory filings[1].

分子量

373.37

Formula

C20H18F3N3O
CAS 号
中文名称

地格列汀
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Denagliptin 相关分类

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Keywords:

Denagliptin483369-58-0GSK823093地格列汀GSK 823093GSK-823093OthersInhibitorinhibitorinhibit

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