2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. DENV-IN-4

DENV-IN-4 是一种有效的 DENV 抑制剂 (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9)。DENV-IN-4 可抑制 DENV2 的表达水平，具有浓度依赖性，并且能降低依赖性 RNA 聚合酶 (RNA-dependent RNA polymerase, RdRp) 的活性。DENV-IN-4 具有抗病毒作用。

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DENV-IN-4 Chemical Structure

DENV-IN-4 Chemical Structure

CAS No. : 2762302-75-8

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DENV-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DENV-IN-4 is a potent DENV inhibitor (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9). DENV-IN-4 can inhibit the expression level of DENV2 with concentration-dependence and reduce RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 has antiviral effect[1].

IC50 & Target

EC50=4.79 μM (DENV)[1]
体外研究
(In Vitro)

DENV-IN-4 (compound 15) (0.064-200 μM; 3 days) has antiviral effect and not related to its toxicity (DENV EC50=4.79 μM, Vero CC50>100, SI>20.9)[1].
DENV-IN-4 (3.125-50 μM in Vero, 3.75-30 μM in A549 and Huh-7; 48 hours) inhibits the expression level of DENV2 with concentration-dependence, and inhibition curves were smoother in Vero[1].
DENV-IN-4 (7.5 and 15 μM; 48 hours) can effectively inhibit DENV infection in Vero cells, and completely inhibited at 15 μM[1].
DENV-IN-4 (0-15 μM; 48 hours) inhibits DENV2 E protein production with good concentration-dependent relationship in Vero cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DENV-IN-4 相关抗体:

Cell Cytotoxicity Assay

Cell Line: Vero[1]
Concentration: 0.064-200 μM
Incubation Time: 3 days
Result: Showed antiviral effect of DENV-IN-4 was not related to its toxicity (Vero EC50=4.79 μM, CC50>100, SI>20.9).

RT-PCR

Cell Line: Vero, A549 and Huh-7 cells[1]
Concentration: 3.125-50 μM in Vero, 3.75-30 μM in A549 and Huh-7
Incubation Time: 48 hours
Result: Inhibited the expression level of DENV2 with concentration-dependence, and inhibition curves were smoother in Vero.

Western Blot Analysis

Cell Line: Vero[1]
Concentration: 7.5 and 15 μM
Incubation Time: 48 hours
Result: Effectively inhibited DENV infection and completely inhibited at 15 μM.

Immunofluorescence

Cell Line: Vero[1]
Concentration: 0-15 μM
Incubation Time: 48 hours
Result: Inhibited DENV2 E protein production with good concentration-dependent relationship.
分子量

516.66

Formula

C28H32N4O4Si
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DENV-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DENV-IN-42762302-75-8DNA/RNA SynthesisDengue virusAntiviralFused tricyclic derivatives of indoline and imidazolidinoneRNA-dependent RNA polymerase (RdRp)Inhibitorinhibitorinhibit

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