2. GPCR/G Protein
  3. GCGR
  4. [Des-His1,Glu9] Glucagon

[Des-His1,Glu9] Glucagon是一种有效的胰高血糖素受体系统多肽拮抗剂。[Des-His1,Glu9] Glucagon 增强胰岛细胞在葡萄糖刺激下释放胰岛素。[Des-His1,Glu9] Glucagon 可用于糖尿病的研究。

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Custom Peptide Synthesis

[Des-His1,Glu9] Glucagon Chemical Structure

[Des-His1,Glu9] Glucagon Chemical Structure

CAS No. : 110121-11-4

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[Des-His1,Glu9] Glucagon 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes[1].

IC50 & Target

Glucagon Receptor[1]
体外研究
(In Vitro)

[Des-His1,Glu9] Glucagon (1 pM-100 μM) does not activate membrane-bound adenylate cyclase up to a concentration of 2×10-4 molar in the cAMP assay on isolated rat liver membranes (from male Sprague Dawley rats)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

[Des-His1,Glu9] Glucagon 相关抗体:
体内研究
(In Vivo)

[Des-His1,Glu9] Glucagon (3.6-4.0 μg/kg for rabbits, 1 mg/kg for rats; i.v.; single dosage) suppresses hyperglycemic effects in rabbits and rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand rabbits (2.8-3.8 kg; fasted for 18 hours)[1]
Dosage: 3.6-4.0 μg/kg
Administration: i.v.; single dosage
Result: Suppressed hyperglycemic response of glucagon.
Animal Model: Male Wistar rats weighing [350-400 mg; hyperglycemia induced by i.p. injection of 65 mg/kg Streptozotocin (HY-13753)][1]
Dosage: 1 mg/kg
Administration: Intravenously administration through the tail vein; single dosage
Result: Decreased blood glucose rapidly, and reduced hyperglycemic effect by 70% within 5 min.
分子量

3359.63

Formula

C148H220N40O48S
CAS 号
Sequence Shortening

SQGTFTSEYSKYLDSRRAQDFVQWLMNT
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

[Des-His1,Glu9] Glucagon 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Des-His1,Glu9] Glucagon110121-11-4GCGRGlucagon Receptorglucagondiabeteshyperglycemiablood glucoseInhibitorinhibitorinhibit

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