2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Dihydroorotate Dehydrogenase Reactive Oxygen Species Ferroptosis
  4. DHODH-IN-26

DHODH-IN-26 (compound B2) 是一种靶向线粒体的 DHODH 抑制剂。DHODH-IN-26 具有抗癌活性，可触发活性氧 (ROS) 的形成，促进线粒体脂质过氧化，诱导铁死亡 (ferroptosis)。

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DHODH-IN-26 Chemical Structure

DHODH-IN-26 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

DHODH-IN-26 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHODH-IN-26 (compound B2) is a mitochondria-targeting DHODH inhibitor. DHODH-IN-26 shows anticancer activity, triggers the formation of reactive oxygen species (ROS), promots mitochondrial lipid peroxidation, and induces ferroptosis[1].

体外研究
(In Vitro)

DHODH-IN-26 (compound B2) (0.01-100 μM, 72 h) 抑制 4T1、B16F10、U251、GL261、SH-SY5Y、U87 和 A375 细胞的生长[1]。
DHODH-IN-26 (50 and 100 nM) 抑制 B16F10 和 A375 细胞集落形成[1]。
DHODH-IN-26 (50 and 100 nM, 48 h) 降低 B16F10 和 A375 细胞 PD-L1 蛋白的表达[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DHODH-IN-26 相关抗体:

Cell Viability Assay[1]

Cell Line: 4T1, B16F10, U251, GL261, SH-SY5Y, U87, and A375 cells
Concentration: 0.01, 0.1, 1, 10 and100 μM
Incubation Time: 72 h
Result: Inhibited cell growth.

Western Blot Analysis[1]

Cell Line: B16F10 and A375 cells
Concentration: 50 and 100 nM
Incubation Time: 48 h
Result: Decreased the expression of PD-L1.
体内研究
(In Vivo)

DHODH-IN-26 (compound B2) (腹腔注射，50 mg/kg，连续14天)可抑制C57BL/6 小鼠 B16F10 异种移植模型的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10 xenograft model in C57BL/6 mice[1]
Dosage: 50 mg/kg
Administration: I.p.; for 14 days
Result: Reduced tumor volume.
分子量

787.63

Formula

C44H34BrF2N2O3P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DHODH-IN-26 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHODH-IN-26Dihydroorotate DehydrogenaseReactive Oxygen SpeciesFerroptosisDHODHmelanomaB16F10A375reactive oxygen speciesferroptosislipid peroxidationInhibitorinhibitorinhibit

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产品名称：
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目录号：
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