DIDS  (Synonyms: MDL101114ZA free base)

DIDS is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research^[1][2][3][4].

DIDS (0-10 μM) 抑制 RAD51 介导的链交换^[1]。
DIDS (0-20 μM) 抑制 RAD51 与 DNA 的结合^[1]。
DIDS（10 μM；0-60 min）在 DNA 不存在的情况下刺激 RAD51 的 ATP 水解活性^[1]。
DIDS (50-400 μM) 可防止对 ALA-SDT 诱导的细胞死亡。然而，50 μM 剂量无抑制作用，400 μM 剂量不会显著降低细胞活力^[2]。
DIDS (100 μM) 显著抑制 caspase-3 和 caspase-9 激活^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

454.52

C₁₆H₁₀N₂O₆S₄

53005-05-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ishida T, et, al. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 2009 Jun;37(10):3367-76.  [Content Brief]

  [2]. Lepke S, et, al. A study of the relationship between inhibition of anion exchange and binding to the red blood cell membrane of 4,4'-diisothiocyano stilbene-2,2'-disulfonic acid (DIDS) and its dihydro derivative (H2DIDS). J Membr Biol. 1976 Oct 20;29(1-2):147-77.  [Content Brief]