2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Dihydro-β-erythroidine

Dihydro-β-erythroidine 是一种竞争性烟碱受体 (nicotinic receptor) 拮抗剂。Dihydro-β-erythroidine 可阻断尼古丁的辨别刺激特性。Dihydro-β-erythroidine 抑制尼古丁诱导的抗焦虑作用。

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Dihydro-β-erythroidine Chemical Structure

Dihydro-β-erythroidine Chemical Structure

CAS No. : 23255-54-1

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Dihydro-β-erythroidine 的其他形式现货产品:

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Other Forms of Dihydro-β-erythroidine:

Dihydro-β-erythroidine 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
1.2 μM
Compound: DHbetaE
Antagonist activity at mouse alpha4beta2 nAChR transfected in HEK293 cells by FLIPR membrane potential blue (FMP) assay
Antagonist activity at mouse alpha4beta2 nAChR transfected in HEK293 cells by FLIPR membrane potential blue (FMP) assay
[PMID: 25050162]
HEK293 IC50
100 μM
Compound: DHbetaE
Antagonist activity at rat alpha3beta4 nAChR transfected in HEK293 cells by FLIPR membrane potential blue (FMP) assay
Antagonist activity at rat alpha3beta4 nAChR transfected in HEK293 cells by FLIPR membrane potential blue (FMP) assay
[PMID: 25050162]
Oocyte IC50
0.011 μM
Compound: DhbetaE
Antagonist activity at (alpha4beta2)2alpha5 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced current after 2 mins by two-electrode voltage clamp assay
Antagonist activity at (alpha4beta2)2alpha5 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced current after 2 mins by two-electrode voltage clamp assay
[PMID: 23561269]
Oocyte IC50
0.02 μM
Compound: DhbetaE
Antagonist activity at (alpha4beta2)2alpha4 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced current after 2 mins by two-electrode voltage clamp assay
Antagonist activity at (alpha4beta2)2alpha4 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced current after 2 mins by two-electrode voltage clamp assay
[PMID: 23561269]
Oocyte IC50
0.41 μM
Compound: DhbetaE
Antagonist activity at (alpha4beta2)2beta2 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced current after 2 mins by two-electrode voltage clamp assay
Antagonist activity at (alpha4beta2)2beta2 nAChR (unknown origin) expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced current after 2 mins by two-electrode voltage clamp assay
[PMID: 23561269]
体内研究
(In Vivo)

Dihydro-β-erythroidine (0.5, 1.6, 5.0 mg/kg; s.c.) blocks the discriminative stimulus properties of nicotine in rats[1].
Dihydro-β-erythroidine (100 ng) shows antagonism of the anxiolytic effect of nicotine in the dorsal raphe´ nucleus in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 200-250 g male hooded Lister rats[1]
Dosage: 0.5, 1.6, 5.0 mg/kg
Administration: S.c.
Result: Prevented the development of CTAs (conditioned taste aversion) and blocked the discriminative stimulus effect of nicotine (0.2 or 0.4 mg/kg SC) for 45 min after its administration.
分子量

275.34

Formula

C16H21NO3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dihydro-β-erythroidine 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydro-β-erythroidine23255-54-1nAChRNicotinic acetylcholine receptorsnicotineanxiolyticInhibitorinhibitorinhibit

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