1. Cell Cycle/DNA Damage Epigenetics
  2. Nucleoside Antimetabolite/Analog DNA Methyltransferase
  3. Dihydro-5-azacytidine acetate

Dihydro-5-azacytidine acetate  (Synonyms: DHAC acetate; NSC 264880 acetate)

目录号: HY-106689A
产品使用指南

Dihydro-5-azacytidine acetate (DHAC) 是一种核苷类似物,可掺入 DNA 并抑制 DNA 甲基化 (DNA methylation)。Dihydro-5-azacytidine acetate 具有抗肿瘤活性。

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Dihydro-5-azacytidine acetate Chemical Structure

Dihydro-5-azacytidine acetate Chemical Structure

CAS No. : 2470972-18-8

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Other Forms of Dihydro-5-azacytidine acetate:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dihydro-5-azacytidine acetate (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine acetate has an antitumor activity[1][2].

体外研究
(In Vitro)

Methylation studies show that an LD10 dose of [3H]DHAC results in a 25.06% hypomethylation of DNA in L1210/0 cells and a 46.32% hypomethylation in a deoxycytidine kinase mutant cell line L1210/dCK(-), compared with their respective controls[2].
Dihydro-5-azacytidine (DHAC) competes with cytidine triphosphate for incorporation into RNA, leading to ribosomal degradation and defective protein synthesis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In tumor-bearing mice (injected with L1210/0 cells), after an LD10 dose of Dihydro-5-azacytidine (DHAC; 1500 mg/kg), the plasma peak concentration achieved is 317 μM and is eliminated biexponentially, with a t1/2 α of 1.03 h and a t1/2 β of 5 h[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

306.27

Formula

C10H18N4O7

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Dihydro-5-azacytidine acetate
目录号:
HY-106689A
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