Dimethylnitrosamine  (Synonyms: 马来酸咪喹莫特; R 837 maleate)

Dimethylnitrosamine (NDMA) is a potent hepatotoxin, carcinogen and mutagen. Dimethylnitrosamine can be used to induces liver tumors^[1][2].

Dimethylnitrosamine 可用动物建模，构建肝肿瘤模型。Dimethylnitrosamine 在比格犬中的药代动力学研究显示，静脉注射后的 Dimethylnitrosamine 浓度双相下降，具有 19 分钟的平均分布半衰期和 73 分钟的平均消除半衰期。在低剂量 (0.5和1.0 mg/kg) 下 Dimethylnitrosamine 的消除速率与其血药浓度成正比，但在高剂量 (5.0 mg/kg) 下代谢饱和。Dimethylnitrosamine 的平均全身清除率为 43.3 mL/min/kg，稳态分布体积为 1.9 L/kg，平均停留时间为 45 分钟，且口服生物利用度高达93%^[3][4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

74.08

C₂H₆N₂O

62-75-9

马来酸咪喹莫特

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Haggerty HG, et, al. Role of metabolism in dimethylnitrosamine-induced immunosuppression: a review. Toxicology. 1990 Jul;63(1):1-23.  [Content Brief]

  [2]. Takayama S, et, al. Sequential effects of chemically different carcinogens, dimethylnitrosamine and 4-dimethylaminoazobenzene, on hepatocarcinogenesis in rats. Int J Cancer. 1969 Jul 15;4(4):373-83.  [Content Brief]

  [3]. Gombar CT, et al. Pharmacokinetics of N-nitrosodimethylamine in beagles. Cancer Res. 1987 Jan 15;47(2):343-7.  [Content Brief]

  [4]. Craddock VM. Liver carcinomas induced in rats by single administration of dimethylnitrosamine after partial hepatectomy. J Natl Cancer Inst. 1971 Oct;47(4):899-907.  [Content Brief]