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  3. Dios-Arg diTFA

Dios-Arg diTFA是一种带有精氨酸头基的阳离子脂质,在约5.2-5.3 ppm处显示出明显的双键质子信号。Dios-Arg diTFA与DOPE结合使用,用于绑定siRNA和质粒,以形成用于细胞内运输的阳离子脂质纳米粒子.

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Dios-Arg diTFA Chemical Structure

Dios-Arg diTFA Chemical Structure

CAS No. : 1807353-31-6

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport[1][2].

体外研究
(In Vitro)

Dios-Arg表现出高细胞毒性 (在 H1299 中的 IC50 = 83.5 µg/mL;在HeLa中的IC50 = 74.1 µg/mL),这可能是由于diosgenin对 HMG-CoA 还原酶的抑制作用所致,HMG-CoA还原酶是参与胆固醇生物合成的限速酶[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

912.01

Formula

C43H67F6N5O9

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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产品名称:
Dios-Arg diTFA
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HY-129990
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