2. Cell Cycle/DNA Damage
  3. G-quadruplex
  4. DIZ-3

DIZ-3 是一种基于 G4 配体二聚化策略的选择性多聚体 G4 配体。DIZ-3 插入 G4-G4 界面，稳定高阶结构。DIZ-3 诱导细胞周期停滞和细胞凋亡，从而在端粒 (ALT) 癌细胞的交替延长中抑制细胞增殖。

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DIZ-3 Chemical Structure

DIZ-3 Chemical Structure

CAS No. : 2675490-72-7

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DIZ-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells[1].

体外研究
(In Vitro)

DIZ-3 (0-40 μM; 24 小时) 抑制 ALT 癌细胞系的增殖[1]。
DIZ-3 (0.6-2.5 μM; 24小时) 诱导 U2OS 细胞周期停滞和细胞凋亡[1]。
DIZ-3 (0.12, 0.25, 0.5 μM; 7 天) 导致 U2OS 细胞集落形成[1]。
DIZ-3 (0.12, 0.25, 0.5 μM; 24小时) 显着抑制 U2OS 细胞的迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DIZ-3 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Human bone osteosarcoma U2OS cells, normal BJ fibroblasts
Concentration: 0-40 μM
Incubation Time: 24 hours
Result: Caused a significant dose-dependent cytotoxic effect on U2OS cancer cells with an IC50 of 2.1 µM.
Induced much weaker growth inhibition on normal BJ fibroblasts with an IC50 of 29.3 µM.

Apoptosis Analysis[1]

Cell Line: U2OS cells
Concentration: 0.6, 1.2, 2.5 μM
Incubation Time: 24 hours
Result: Induced significant apoptosis in U2OS cells (the percentage of apoptotic cells increased from 10.1% to 24.9%).

Cell Cycle Analysis[1]

Cell Line: U2OS cells
Concentration: 0.6, 1.2, 2.5 μM
Incubation Time: 24 hours
Result: Induced the apparent accumulation of cells in the S phase (increasing from 24.0% to 32.2%) in a dose-dependent manner.
分子量

746.89

Formula

C46H44F2N8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DIZ-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DIZ-32675490-72-7DIZ3DIZ 3G-quadruplexmultimeric G4G4 interfacecell cycle arrestalternative lengthening of telomereALT cellsInhibitorinhibitorinhibit

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