DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate  (Synonyms: DL-3-羟基-3-甲戊二酰辅酶A二钠水合物; HMG-CoA disodium hydrate)

DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor^[1][2].

DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate comes from acetyl-coa and acetyl-CoA converted from HMG-CoA synthetase, mainly dependents on oxidative reactions in mitochondria^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C₂₇H₄₄N₇Na₂O₂₁P₃S.xH₂O

103476-21-7

固体

White to off-white

DL-3-羟基-3-甲戊二酰辅酶A二钠水合物

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Millán Núñez-Cortés J, et al. Fármacos hipolipemiantes y PCSK9 [Lipid-lowering drugs and PCSK9]. Clin Investig Arterioscler. 2016 May;28 Suppl 2:9-13. Spanish.  [Content Brief]

  [2]. Wang Wei, er al. The Key Enzyme of Cholesterol Synthesis Pathway:HMG CoA Reductase and Disease. PROGRESS IN PHYSIOLOGICAL SCIENCES. 1999. (01):7-11.