2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. DNA crosslinker 2 dihydrochloride

DNA crosslinker 2 dihydrochloride 

目录号: HY-144335
产品使用指南

摩尔计算器

DNA crosslinker 2 (dihydrochloride) 是一种有效的 DNA 小沟结合剂，与 DNA 的结合亲和力 (ΔTm) 为 1.2 °C。DNA crosslinker 2 (dihydrochloride) 对癌细胞 NCI-H460、A2780 和 MCF-7 有一定的抑制活性。DNA crosslinker 2 (dihydrochloride) 可用于抗癌研究。

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DNA crosslinker 2 dihydrochloride Chemical Structure

DNA crosslinker 2 dihydrochloride Chemical Structure

CAS No. : 2761734-25-0

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DNA crosslinker 2 dihydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DNA crosslinker 2 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.2 °C. DNA crosslinker 2 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 2 (dihydrochloride) can be used for researching anticancer[1].

IC50 & Target

DNA minor groove[1]
体外研究
(In Vitro)

DNA crosslinker 2 (dihydrochloride) (compound 3) (100 μM; 48 h or 96 h) exhibits inhibitory activity against NCI-H460, A2780 and MCF-7[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DNA crosslinker 2 dihydrochloride 相关抗体:

Cell Proliferation Assay

Cell Line: NCI-H460, A2780 and MCF-7[1]
Concentration: 100 μM
Incubation Time: 48 h (NCI-H460) and 96 h (A2780 and MCF-7)
Result: Exhibited inhibitory activity against NCI-H460, A2780 and MCF-7 with inhibition percentage of 35%, 33% and 23% at 100 μM.
分子量

401.29

Formula

C15H22Cl2N8O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DNA crosslinker 2 dihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNA crosslinker 22761734-25-0DNA crosslinker2DNA crosslinker-2DNA Alkylator/CrosslinkerAnticancerAntiproliferationDNAMinor grooveNCI-H460A2780MCF-7Inhibitorinhibitorinhibit

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