2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC DNA Methyltransferase
  4. DNMT/HDAC-IN-1

DNMT/HDAC-IN-1 (Compund 15a) 是一种 DNMT 和 HDAC 双重抑制剂，对 HDAC1 和 HDAC6 的 IC50 值分别为 56.84 nM 和 17.39 nM。DNMT/HDAC-IN-1 可诱导细胞凋亡 (Apoptosis)，用于肿瘤的研究。

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DNMT/HDAC-IN-1 Chemical Structure

DNMT/HDAC-IN-1 Chemical Structure

CAS No. : 2095619-17-1

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DNMT/HDAC-IN-1 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 DNA Methyltransferase 亚型特异性产品:

查看所有亚型
DNA Methyltransferase DNMT1 DNMT3 MGMT

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DNMT/HDAC-IN-1 (Compund 15a) is a dual DNMT and HDAC inhibitor with IC50 values for HDAC1 and HDAC6 are 56.84 nM and 17.39 nM respectively. DNMT/HDAC-IN-1 can induce apoptosis and be used in tumor research.

IC50 & Target

HDAC1

56.84 nM (IC50)

HDAC6

17.39 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
K562 IC50
2.85 μM
Compound: 15a
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 28419930]
U-937 IC50
1.06 μM
Compound: 15a
Antiproliferative activity against human U937 cells after 72 hrs by MTT assay
Antiproliferative activity against human U937 cells after 72 hrs by MTT assay
[PMID: 28419930]
体外研究
(In Vitro)

DNMT/HDAC-IN-1 显著抑制 K562 和 U937 增殖，IC50 值分别为 2.85 和 1.06 mM。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DNMT/HDAC-IN-1 相关抗体:

Western Blot Analysis[1]

Cell Line: U937 cells
Concentration: 0, 1, 2.5, 5 μM
Incubation Time: 12 h
Result: induced histone H3K9 and histone H4K8 acetylation and increased P16 expression.

Apoptosis Analysis[1]

Cell Line: U937 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 36 h
Result: induced apoptosis in U937 cells.
体内研究
(In Vivo)
Animal Model: female BALB/c wild-type mice[2]
Dosage: 50 mg/kg
Administration: I.v.; daily; 21 days
Result: inhibited tumor growth.
分子量

412.79

Formula

C19H16ClF3N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DNMT/HDAC-IN-1 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNMT/HDAC-IN-12095619-17-1HDACDNA MethyltransferaseHistone deacetylasesDNMTsDNA MTasesEpigenetic targetsMulti-targetAntitumor bioactivityDNMTInhibitorinhibitorinhibit

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