2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. [DPen2, Pen5] Enkephalin

[DPen2, Pen5] Enkephalin 是 [Leu5]-Enkephalin (HY-P0288) 的 δ-阿片受体 (δ-opioid receptor) 选择性类似物。

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Custom Peptide Synthesis

[DPen2, Pen5] Enkephalin Chemical Structure

[DPen2, Pen5] Enkephalin Chemical Structure

CAS No. : 88373-72-2

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规格 是否有货
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Customer Review

[DPen2, Pen5] Enkephalin 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

[DPen2, Pen5] Enkephalin is a δ-opioid receptor selective analog of [Leu5]-Enkephalin (HY-P0288)[1].

IC50 & Target

δ Opioid Receptor/DOR

 

体内研究
(In Vivo)

[DPen2, Pen5] Enkephalin (0-3.32 μg/kg, IP) impairs acquisition of an automated jump-up avoidance response in rats and acquisition of a one-way active avoidance response in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (260-280 g)[1]
Dosage: 0, 1.16, 11.6 μg/kg
Administration: IP, administered on day 2 prior to presentation of eight training trials, on subsequent one-way avoidance responding.
Result: Produced a significant impairment of avoidance performance at 1.16 ug/kg, while the 11.6 ug/kg dose was without significant effect.
Animal Model: Male Sprague-Dawley rats (260-280 g)[1]
Dosage: 0, 0.332, 3.32 μg/kg
Administration: IP, administered on day 1 immediately after presentation of two escape-only trials, on subsequent day 2 one-way avoidance responding in the second experiment
Result: Produced a significant enhancement of avoidance performance at 0.332 ug/kg, while the 3.32 ug/kg dose was without significant effect.
分子量

645.79

Formula

C30H39N5O7S2
CAS 号
Sequence Shortening

Y-{d-Pen}-GF-{Pen} (Disulfide bridge: d-Pen2-Pen5)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

[DPen2, Pen5] Enkephalin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[DPen2, Pen5] Enkephalin88373-72-2Opioid Receptoravoidance responseδ-Opioid ReceptorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P3546
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