2. Anti-infection
  3. Influenza Virus
  4. DS-22-inf-021

DS-22-inf-021 是一种神经氨酸酶 (NA) 抑制剂。DS-22-inf-021 对流感病毒具有抗病毒活。

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DS-22-inf-021 Chemical Structure

DS-22-inf-021 Chemical Structure

CAS No. : 945170-74-1

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DS-22-inf-021 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DS-22-inf-021 is a neuraminidase (NA) inhibitor. DS-22-inf-021 has antiviral activity against influenza viruses[1].

体外研究
(In Vitro)

DS-22-inf-021 抑制 IBV (B/Samara/32/2018 Yamagata 谱系) 和携带 H275Y 突变的耐药 IAV A/Vladivostok/2/2009 (H1N1 pdm09) 的 NA 活性，IC50 值分别为 9.1 μM 和 14.7 µM[1]。
DS-22-inf-021 (0.5-50 μM，10 小时) 在感染 IAV 和 IBV 株的 MDCK 细胞中显示出抗病毒活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DS-22-inf-021 相关抗体:
体内研究
(In Vivo)

DS-22-inf-021 (20-100 mg/kg，腹腔注射，每天两次，持续 5 天，监测 14 天) 提高感染 IAV 和 IBV 的小鼠的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old female BALB/c mice, intranasally inoculated with 50 μL of five 50 % mouse lethal doses of IAV and IBV[1].
Dosage: 20, 50 and 100 mg/kg
Administration: After 2 h post-infection, i.p. injection
Result: Reached 85 % protection at 100 mg/kg dose. For the B/Samara/32/2018 strain, it was observed that 100 % of mice treated with DS-22-inf-021 at 100 mg/kg.
分子量

337.42

Formula

C20H23N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DS-22-inf-021 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS-22-inf-021945170-74-1Influenza VirusMDCK cellIAVIBVinfluenza virusesInhibitorinhibitorinhibit

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目录号：
HY-163364
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