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  4. (E)-2'-Hydroxy-3,4-dimethoxychalcone

(E)-2'-Hydroxy-3,4-dimethoxychalcone (compound 7) 是一种具有口服活性的 Chalcone 衍生物，并具有抗肿瘤活性。

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(E)-2'-Hydroxy-3,4-dimethoxychalcone Chemical Structure

(E)-2'-Hydroxy-3,4-dimethoxychalcone Chemical Structure

CAS No. : 79140-20-8

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(E)-2'-Hydroxy-3,4-dimethoxychalcone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(E)-2'-Hydroxy-3,4-dimethoxychalcone (compound 7) is a Chalcone derivative with orally active. (E)-2'-Hydroxy-3,4-dimethoxychalcone has anti-tumour activities[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
95 μM
Compound: 24
Growth inhibition of MCF7 cells by sulforhodamine assay
Growth inhibition of MCF7 cells by sulforhodamine assay
[PMID: 17383189]
MDCK-II IC50
4.97 μM
Compound: 5
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry
[PMID: 22112540]
Neutrophil IC50
15 μM
Compound: 13
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
[PMID: 33006891]
Neutrophil IC50
6.4 μM
Compound: 13
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
[PMID: 33006891]
TK-10 IC50
90 μM
Compound: 24
Growth inhibition of TK10 cells by sulforhodamine assay
Growth inhibition of TK10 cells by sulforhodamine assay
[PMID: 17383189]
分子量

284.31

Formula

C17H16O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(E)-2'-Hydroxy-3,4-dimethoxychalcone 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-2'-Hydroxy-3,4-dimethoxychalcone79140-20-8OthersAnti-tumourchalconeflavonoidorallyInhibitorinhibitorinhibit

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