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  6. (E)-Naringenin chalcone

(E)-Naringenin chalcone 是一种具有口服活性的抗过敏剂。(E)-Naringenin chalcone 还具有抗氧化、抗炎活性。(E)-Naringenin chalcone 可改善脂肪细胞的功能。(E)-Naringenin chalcone 可抑制大鼠腹膜肥大细胞的组胺的释放。

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(E)-Naringenin chalcone Chemical Structure

(E)-Naringenin chalcone Chemical Structure

CAS No. : 25515-46-2

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Other Forms of (E)-Naringenin chalcone:

(E)-Naringenin chalcone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell[1][2][4].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
> 10 μM
Compound: 2b
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 26690274]
MDA-MB-231 IC50
> 10 μM
Compound: 2b
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 26690274]
体外研究
(In Vitro)

(E)-Naringenin chalcone (25-125 μg/mL, 10 min) inhibits histamine release from rat peritoneal mast cells, with an IC50 value of 68 μg/mL[1].
(E)-Naringenin chalcone (25-50 μM, 8 days) improves adipocyte (3T3-L1) functions by enhancing adiponectin production[2].
(E)-Naringenin chalcone (25-100 μM, 24 h) stimulates the activity of PPARγ in NIH-3T3 cells[2].
(E)-Naringenin chalcone (0-200 μM 24 h) inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(E)-Naringenin chalcone 相关抗体:

RT-PCR[2]

Cell Line: 3T3-L1 adipocytes
Concentration: 25-100 μM
Incubation Time: 8 days
Result: Increased adiponectin mRNA levels up to 8.0-fold in a dose-dependent manner.

Western Blot Analysis[4]

Cell Line: RAW 264 macrophages
Concentration: 0,25, 50, 100, 200 μM
Incubation Time: 24 h
Result: Suppressed the degradation of IκB-α.
体内研究
(In Vivo)

(E)-Naringenin chalcone (0.8 mg/kg, oral administration) shows anti-allergic effect in type I allergic mice[1].
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse type I allergic model[1]
Dosage: 0.8 mg/kg
Administration: Oral administration
Result: Inhibited the ear-swelling response, with the inhibitory ratio of 46.7%.
Animal Model: Allergic airway inflammation induced in mice[3]
Dosage: 0.8 mg/kg
Administration: Oral administration, daily
Result: Decreased cell numbers of the infiltrating leukocyte and eosinophils.
Decreased Muc5ac and gob-5 expression in the lungs.
分子量

272.26

Formula

C15H12O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(E)-Naringenin chalcone 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-Naringenin chalcone25515-46-2OthersTomato skin extractmast cellanti-allergicinflammationantioxidantadiponectinadipocyteNIH-3T33T3-L1macrophageInhibitorinhibitorinhibit

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