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EBOV-IN-5 (compound 14) 是一种抗病毒剂,可抑制埃博拉病毒 (Ebola virus,EBOV) 的感染。EBOV-IN-5 可以抑制 EBOV 糖蛋白 EBOV-GPcl 与 NPC1 结合,其中 NPC1 是病毒融合/进入所需的不可或缺的宿主受体。

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EBOV-IN-5 Chemical Structure

EBOV-IN-5 Chemical Structure

CAS No. : 68207-15-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EBOV-IN-5 (compound 14) is an antiviral agent that inhibits Ebola virus (EBOV) infection. EBOV-IN-5 inhibits the binding of the EBOV glycoprotein EBOV-GPcl to NPC1, an indispensable host receptor required for viral fusion/entry[1].

IC50 & Target

Ebola virus[1]

体外研究
(In Vitro)

EBOV-IN-5 (compound 14) 对 HeLa 细胞的 CC50 为 30 μM,且对 Vero 细胞的细胞毒性低,CC50 >100 μM[1]
EBOV-IN-5 (50 μM) 显著干扰 EBOV-GPcl/NPC1 相互作用,对 EBOV-GP-假型病毒 (pEBOV) 的 IC50 为 4.69 μM[1]
EBOV-IN-5 对非洲猪瘟病毒 ASFV 的 IC50 为 35.17 μM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

408.90

Formula

C18H21ClN4O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

EBOV-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
EBOV-IN-5
目录号:
HY-160880
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