2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Efdamrofusp alfa

Efdamrofusp alfa 是一种双特异性融合蛋白。Efdamrofusp alfa 能够中和 VEGF 亚型和 C3b/C4b。Efdamrofusp alfa 可用于新生血管性年龄相关性黄斑变性 (nAMD) 和其他与补体相关的眼部疾病的研究。

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CAS No. : 2375661-82-6

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Efdamrofusp alfa 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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生物活性

Efdamrofusp alfa is a bispecific fusion protein. Efdamrofusp alfa is capable of neutralizing both VEGF isoforms and C3b/C4b. Efdamrofusp alfa can be used for the research of neovascular age-related macular degeneration (nAMD) and other complement-related ocular conditions[1].

种属

Human
体外研究
(In Vitro)

Efdamrofusp alfa (0.135 mg/mL; 0, 6, 12, or 24 h) suppresses endothelial cell migration and tube formation[1].
Efdamrofusp alfa (0-1000 μg/mL) inhibits complement activation in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Efdamrofusp alfa 相关抗体:

Cell Migration Assay [1]

Cell Line: Human primary umbilical vein endothelial cell (HUVEC)
Concentration: 0.135 mg/mL
Incubation Time: 0, 6, 12, or 24 h
Result: Showed a 20.91% reduction in migration.
体内研究
(In Vivo)

Efdamrofusp alfa (13.5 μg; 3 days) inhibits activation ofthe complement system in a mouse model oflaser-induced CNV[1].
Efdamrofusp alfa (1.35 mg; single intravitreal injection) shows favorable safety profiles and exhibited antiangiogenetic efficacy in a nonhuman primate laser-induced CNV model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice[1]
Dosage: 13.5 μg; 13.0 μg
Administration: 3 days; 7days
Result: Significantly reduced C3d deposition.
Reduced vascular leakage at 7 days after laser-induced injury.
Significantly suppressed CNV formation 7 days after laser-induced injury.
Reduced the concentrations of vitreous VEGF-A.
Animal Model: Rhesus monkeys[1]
Dosage: 1.35 mg
Administration: Single intravitreal injection
Result: Decreased the CNV leakage at 14 and 28 days and effectively reduced CNV volume 28 days.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • FLT1 (fms-related tyrosine kinase 1, vascular endothelial growth factor receptor 1, VEGFR-1, VEGFR, FLT, FRT, vascular permeability factor receptor)domain 2 fragment (14-204)-KDR (kinase insert domain receptor, vascular endothelial growth factor receptor 2, VEGFR2, VEGF-R2, FLK1, CD309)domain 3 fragment (206-308)-IGHG1 Fc (Fragment constant (205-431))-CR1 (complement receptor type 1, C3b/C4b receptor, C3BR, Knops blood group, KN, CD35)fragment (1-192)
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参考文献

Efdamrofusp alfa 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Efdamrofusp alfa2375661-82-6VEGFRVascular endothelial growth factor receptorfusion proteinVEGF isoformC3b/C4bneovascular age-related macular degeneration (nAMD)complementInhibitorinhibitorinhibit

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