1. Cell Cycle/DNA Damage Cytoskeleton
  2. Kinesin Microtubule/Tubulin
  3. Eg5-IN-3

Eg5-IN-3 (5) 是一种基于靶向新型变构口袋 (α4/α6/L11) 的 Eg5 抑制剂。Eg5-IN-3 (5) 导致微管蛋白组装畸形,呈现不规则形态,导致典型的有丝分裂阻滞,类似于 Monastrol (HY-101071A)。

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Eg5-IN-3 Chemical Structure

Eg5-IN-3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A)[1].

体外研究
(In Vitro)

Eg5-IN-3 (5) 抑制癌细胞 Eg5 ATPase IC50 值为2.37 ± 0.15 µM。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

429.47

Formula

C23H23N7O2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

产品名称:
Eg5-IN-3
目录号:
HY-162518
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