2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. Eicosapentaenoyl ethanolamide

Eicosapentaenoyl ethanolamide 

目录号: HY-124089
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摩尔计算器

Eicosapentaenoyl ethanolamide 是 omega-3 脂肪酸，一种 N-酰基乙醇胺 (NAE)。Eicosapentaenoyl ethanolamide 是大麻素 CB1/CB2 受体激动剂。Eicosapentaenoyl ethanolamide 是一种代谢信号。Eicosapentaenoyl ethanolamide 抑制饮食限制 (DR) 诱导的野生型动物寿命延长，并抑制 TOR 通路突变体的寿命延长。

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Eicosapentaenoyl ethanolamide Chemical Structure

Eicosapentaenoyl ethanolamide Chemical Structure

CAS No. : 109001-03-8

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Eicosapentaenoyl ethanolamide 相关抗体

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs). Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR)-induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant[1][2].

IC50 & Target[1]

CB1

 

CB2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RBL-2H3 IC50
24 μM
Compound: 15; EPEA
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2
[PMID: 31618024]
体外研究
(In Vitro)

Eicosapentaenoyl ethanolamide (EPEA) induces cell death in both LNCaP and PC3 cells (IC50=16.19 μM). EPEA (24 hours) did not result in any significant changes in the G1, S or G2 phases of the cell cycle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Eicosapentaenoyl ethanolamide 相关抗体:
分子量

345.52

Formula

C22H35NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Eicosapentaenoyl ethanolamide 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eicosapentaenoyl ethanolamide109001-03-8Cannabinoid Receptoromega-3 fatty acidN-acylethanolamineslifespan extensionTOR pathway mutantEPEALNCaPPC3 cellsInhibitorinhibitorinhibit

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