2. GPCR/G Protein
  3. GCGR
  4. Elsiglutide

Elsiglutide  (Synonyms: ZP1846)

目录号: HY-P3498
产品使用指南

摩尔计算器

Elsiglutide (ZP1846) 是一种 GLP-2 类似物和一种具有口服活性和选择性的 GLP-2 受体激动剂，能够增加细胞增殖，减少肠道细胞凋亡 (apoptosis)。Elsiglutide 改善了 Lapatinib (HY-50898) 诱导的大鼠腹泻症状。

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Elsiglutide Chemical Structure

Elsiglutide Chemical Structure

CAS No. : 914009-84-0

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Elsiglutide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Elsiglutide (ZP1846) is a GLP-2 analogue, an orally active and selective GLP-2 receptor agonist, increases cell proliferation and reduces apoptosis in the intestine. Elsiglutide improves Lapatinib (HY-50898)-induced diarrhoea in rat model[1][2].

体内研究
(In Vivo)

Elsiglutide (500 mg/kg; p.o.; once daily; 4 times per week for 4 weeks) reduces the most severe diarrhoea seen from Lapatinib (500 mg/kg; p.o.) in rat model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Albino Wistar rats (250-280 g)[1]
Dosage: 500 mg/kg, with or not 500 mg/kg Lapatinib
Administration: Oral gavage; once daily, 4 non-consecutive days per week with vehicle solution being administered on the other 3 days for 4 weeks
Result: Resulted less incidence of diarrhoea compared to lapatinib alone.
Signifcantly less weight gain from day 7 of treatment compared to control.
Clinical Trial
分子量

4317.98

Formula

C196H323N53O56
CAS 号
Sequence

His-Gly-Glu-Gly-Ser-Phe-Ser-Ser-Glu-Leu-Ser-Thr-Ile-Leu-Asp-Ala-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Ala-Trp-Leu-Ile-Ala-Thr-Lys-Ile-Thr-Asp-Lys-Lys-Lys-Lys-Lys-Lys-NH2
Sequence Shortening

HGEGSFSSELSTILDALAARDFIAWLIATKITDKKKKKK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Elsiglutide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elsiglutide914009-84-0ZP1846ZP 1846ZP-1846GCGRGlucagon Receptorbreast cancerdiarrhoeaelsiglutidelapatinibInhibitorinhibitorinhibit

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