2. Immunology/Inflammation Protein Tyrosine Kinase/RTK NF-κB Apoptosis
  3. IRAK FLT3 NF-κB MyD88 Apoptosis
  4. Emavusertib tosylate

Emavusertib tosylate  (Synonyms: CA-4948 tosylate)

目录号: HY-135317C
产品使用指南 技术支持

Emavusertib tosylate (CA-4948 tosylate) 是 Emavusertib (HY-135317) 的甲苯磺酸盐形式。Emavusertib tosylate 是口服有效的 IRAK4 (IC50=57 nM) 和 FLT3 抑制剂。Emavusertib tosylate 可抑制 NF-κB 和 MyD88 信号通路，减少促炎细胞因子（如 IL-6 和 IL-10）的产生，从而表现出抗炎和对癌细胞的抗增殖活性，诱导细胞凋亡 (apoptosis)。Emavusertib tosylate 在小鼠模型中表现出抗肿瘤活性。

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Emavusertib tosylate Chemical Structure

Emavusertib tosylate Chemical Structure

CAS No. : 2376399-41-4

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Emavusertib tosylate 的其他形式现货产品:

Other Forms of Emavusertib tosylate:

Emavusertib tosylate 相关抗体

Top Publications Citing Use of Products

查看 IRAK 亚型特异性产品:

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IRAK1 IRAK4

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Emavusertib tosylate (CA-4948 tosylate) is the tosylate salt form of Emavusertib (HY-135317). Emavusertib tosylate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib tosylate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib tosylate exhibits antitumor activity in mouse model[1][2][3].

分子量

663.70

Formula

C31H33N7O8S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Emavusertib tosylate 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emavusertib2376399-41-4CA-4948CA4948CA 4948IRAKFLT3NF-κBMyD88ApoptosisInterleukin-1 receptor associated kinaseIL-1R associated kinaseCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Nuclear factor-κBNuclear factor-kappaBABC DLBCLMCLAMLselectiveorally activeInhibitorinhibitorinhibit

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