2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Eprociclovir

Eprociclovir  (Synonyms: A-5021)

目录号: HY-16740
产品使用指南

摩尔计算器

Eprociclovir 是一种核苷类似物的抗病毒化合物。Eprociclovir 的三磷酸形式在病毒感染的细胞内通过病毒和可能的细胞酶 (包括病毒胸苷激酶) 转化为活性形式，从而抑制病毒 DNA 聚合酶的活性。Eprociclovir 的主要活性是对抗疱疹病毒，包括但不限于巨细胞病毒 (CMV) 和单纯疱疹病毒 (HSV)。Eprociclovir 可用于由敏感病毒干扰的研究。

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Eprociclovir Chemical Structure

Eprociclovir Chemical Structure

CAS No. : 145512-85-2

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Other Forms of Eprociclovir:

Eprociclovir 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eprociclovir is an antiviral drug with nucleoside analogues. The triphosphate form of Eprociclovir is converted into the active form within virus-infected cells by the virus and possible cellular enzymes, including the viral thymidine kinase, thereby inhibiting the activity of the viral DNA polymerase. The primary activity of Eprociclovir is against herpes viruses, including but not limited to cytomegalovirus (CMV) and herpes simplex virus (HSV). Eprociclovir can be used in studies interfered with by sensitive viruses[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
> 100 μg/mL
Compound: 3a
Inhibitory activity against 1RF strain of HIV-1 by plaque reduction assay in CEM cells
Inhibitory activity against 1RF strain of HIV-1 by plaque reduction assay in CEM cells
[PMID: 9548818]
HEL IC50
0.67 μg/mL
Compound: 1
Tested for inhibitory activity against Varicella zoster virus(VZV) by plaque reduction assay using HEL cells
Tested for inhibitory activity against Varicella zoster virus(VZV) by plaque reduction assay using HEL cells
[PMID: 10649983]
HFF IC50
0.2 μg/mL
Compound: 3a
Inhibitory activity against DM625 strain of zoster virus(VZV) by plaque reduction assay in HFF cells
Inhibitory activity against DM625 strain of zoster virus(VZV) by plaque reduction assay in HFF cells
[PMID: 9548818]
Vero IC50
0.02 μg/mL
Compound: 3a
Inhibition of Tomioka strain of herpes simplex virus( Tomioka strain of HSV-1) by quantitative CPE reduction assay in vero cells
Inhibition of Tomioka strain of herpes simplex virus( Tomioka strain of HSV-1) by quantitative CPE reduction assay in vero cells
[PMID: 9548818]
分子量

265.27

Formula

C11H15N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Eprociclovir 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eprociclovir145512-85-2A-5021A5021A 5021DNA/RNA SynthesisNucleoside analoguesDNA polymeraseherpes virussensitive virusInhibitorinhibitorinhibit

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