2. Apoptosis
  3. Apoptosis
  4. ERK-IN-6

ERK-IN-6 (compound 6g) 是有效的食管鳞状细胞癌 (ESCC) 的抗增殖剂。ERK-IN-6 通过 ERK 通路诱导细胞凋亡。ERK-IN-6 可用于食管鳞状细胞癌的研究。

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ERK-IN-6 Chemical Structure

ERK-IN-6 Chemical Structure

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ERK-IN-6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ERK-IN-6 (compound 6g) is an potent anti-proliferation agent against esophageal squamous cell carcinoma (ESCC). ERK-IN-6 induces cell apoptosis via ERK pathway. ERK-IN-6 can be used for the research of ESCC[1].

IC50 & Target

IC50: 16.8 µM (KYSE-30), 10.07 µM (KYSE-150), 13 µM (HET-1A), 202.2 µM (NES-G4T)[1]
体外研究
(In Vitro)

ERK-IN-6 (0-10 µM; 72 h) inhibits cell proliferation of ESCC cells[1].
ERK-IN-6 (10 µM; 48-72 h) induces cell apoptosis through the ERK pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ERK-IN-6 相关抗体:

Cell Proliferation Assay[1]

Cell Line: KYSE-30, KYSE-150, HET-1A and NES-G4T cell lines
Concentration: 0-10 µM
Incubation Time: 72 hours
Result: Dose-dependently inhibited cell proliferation of KYSE-30, KYSE-150, HET-1A and NES-G4T cells with IC50 values of 16.8, 10.07, 13 and 202.2 µM, respectively.

Apoptosis Analysis[1]

Cell Line: KYSE-30 and KYSE-150 cell lines
Concentration: 10 µM
Incubation Time: 48 and 72 hours
Result: Induced KYSE-30 and KYSE-150 cell apoptosis with the loss of nuclei integrity at 72 h.

Western Blot Analysis[1]

Cell Line: KYSE-150 and NES-G4T cell lines
Concentration: 10 µM
Incubation Time: 4, 8 and 12 hours
Result: Time-dependently down regulated pERK.
分子量

448.33

Formula

C19H18BrN3O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ERK-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERK-IN-6ApoptosisthiazolidineESCCcell proliferationapoptosisERK pathwayInhibitorinhibitorinhibit

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